Alkem set up its research and development facility for ANDA development at Taloja in 2003.[3] In 2006 anti-infective drug Taxim of Alkem became the first anti-infective drug in the Indian pharmaceutical industry to cross 1,000 million in terms of domestic sales in India.[4] In 2014 Clavam another drug from Alkem crossed 2,000 million mark in terms of domestic sales in India.In 2007 the company filed its first ANDA for drug Amlodipine which was approved in 2009.[3] Alkem has developed a portfolio of 705 branded generic drugs, with 13 of the brands featured among the top 300 brands in India for the fiscal year 2015 and a portfolio of 705 brands in India in the six months ended 30 September 2015. Alkem have 21 manufacturing facilities, 19 in India and 2 in US. 5 of the facilities are US FDA, TGA, UK MHRA approved.